Chapter 14
 Second Edition
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Arvat E, Camanni F, Ghigo E: "Age-related growth hormone-releasing activity of growth hormone secretagogues in humans." Acta Paediatrica. Supplement (1997) Nov;423:92-96.

Benbassat CA, Maki KC, Unterman TG: "Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures." Journal of Clinical Endocrinology and Metabolism (1997) May;82(5):1484-1491.

Borst SE, Lowenthal DT: "Role of IGF-I in muscular atrophy of aging." Endocrine (1997) Aug;7(1):61-63.

Brownlee M: "Advanced protein glycosylation in diabetes and aging." Annual Review of Medicine (1995) 46:223-234.

Brzezinski A: "Melatonin in humans." New England Journal of Medicine (1997) Jan 16;336(3):186-195.

Chan K, Spencer EM: "General aspects of insulin-like growth factor binding proteins." Endocrine (1997) Aug;7(1):95-97.

Christopher-Hennings J, Kurzman ID, Haffa AL, Kemnitz JM, Macewen EG: "The effects of high fat diet and dehydriepiandrosterone (DHEA) administration in the rhesus monkey." In Vivo (1995)  9:415-420.

Cohen MP, Ziyadeh FN: "Role of Amadori-modified nonenzymatically glycated serum proteins in the pathogenesis of diabetic nephropathy." Journal of the American Society of Nephrology (1996) Feb;7(2):183-190.

Conover CA: "IGFs and cellular aging." Endocrine (1997) Aug;7(1):93-94.

Delagrange P, Guardiola-Lemaitre B: "Melatonin, its receptors, and relationships with biological rhythm disorders." Clinical Neuropharmacology (1997) Dec;20(6):482-510.

Diamond P, Cusan L, Gomez JL, Belanger A, Labrie F: "Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women." Journal of Endocrinology (1996) Sep;150 Suppl:S43-S50.

Gelato MC, Frost RA: "IGFBP-3. Functional and structural implications in aging and wasting syndromes." Endocrine (1997) Aug;7(1):81-85.

Gerbitz KD, Gempel K, Brdiczka D: "Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit." Diabetes (1996) Feb;45(2):113-126.

Griebling TL, Nygaard IE: "The role of estrogen replacement therapy in the management of urinary incontinence and urinary tract infection in postmenopausal women." Endocrinology and Metabolism Clinics of North America (1997) Jun;26(2):347-360.

Grossman A, Rabinovitch PS, Lane MA, Jinneman JC, Ingram DK, Wolf NS, Cutler RG, Roth GS: "Influence of Age, Sex, and Dietary Restriction on Intracellular Free Calcium Responses of CD4+ Lymphocytes in Rhesus Monkeys (Macaca mulatta),." J. Cell Physiol (1995) 162(2):298- 303.

Guldner J, Schier T, Friess E, Colla M, Holsboer F, Steiger A: "Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly." Neurobiology of Aging (1997) Sep;18(5):491-495.

Hammond CB: "Menopause and hormone replacement therapy: an overview." Obstetrics and Gynecology (1996) Feb;87(2 Suppl):2S-15S.

Hindmarsh PC, Fall CH, Pringle PJ, Osmond C, Brook CG: "Peak and trough growth hormone concentrations have different associations with the insulin-like growth factor axis, body composition, and metabolic parameters." Journal of Clinical Endocrinology and Metabolism (1997) Jul;82(7):2172-2176.

Hobbs MV, Ernst DN: "T cell differentiation and cytokine expression in late life." Developmental and Comparative Immunology (1997) Nov;21(6):461-470.

Hornick TR, Kowal J: "Clinical epidemiology of endocrine disorders in the elderly." Endocrinology and Metabolism Clinics of North America (1997) Mar;26(1):145-163.

Hornsby PJ: "DHEA: a biologist's perspective." Journal of the American Geriatrics Society (1997) Nov;45(11):1395-1401.

Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Nicolson MA, Hansen BC: "Regulation of Obese (ob) mRNA and plasma leptin levels in rhesus monkeys: effects of insulin, body weight, and non-insulin-dependent diabetes mellitus." J. Biol. Chem. (1996)  271:2527-2533.

Huang Z, Bodkin NL, Ortmeyer HK, Hansen BC, Shuldiner AR:  "Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic Rhesus monkey." J. Clin. Invest. (1994); 94:1289-1296.

Ivy JL: "Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus." Sports Medicine (1997) Nov;24(5):321-336.

Janssen JA, Stolk RP, Pols HA, Grobbee DE, Lamberts SW: "Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease." Arteriosclerosis, Thrombosis, and Vascular Biology (1998) Feb;18(2):277-282.

Jorgensen JO, Vahl N, Fisker S, Norrelund H, Nielsen S, Dall R, Christiansen JS: "Somatopause and adiposity." Hormone Research (1997) 48 Suppl 5:101-104.

Khorram O, Laughlin GA, Yen SS: "Endocrine and metabolic effects of long-term administration of [Nle27] growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women." Journal of Clinical Endocrinology and Metabolism (1997) May;82(5):1472-1479.

Khorram O, Yeung M, Vu L, Yen SS: "Effects of [norleucine27] growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women." Journal of Clinical Endocrinology and Metabolism (1997) Nov;82(11):3590-3596.

Khorram O: "DHEA: a hormone with multiple effects." Current Opinion in Obstetrics and Gynecology (1996) Oct;8(5):351-354.

Krentz AJ, Nattrass M: "Insulin resistance: a multifaceted metabolic syndrome. Insights gained using a low-dose insulin infusion technique." Diabetic Medicine (1996) Jan;13(1):30-39.

Lamberts SW, van den Beld AW, van der Lely AJ: "The endocrinology of aging." Science (1997) Oct 17;278(5337):419-424.

Lichtman R: "Perimenopausal and postmenopausal hormone replacement therapy. Part 2. Hormonal regimens and complementary and alternative therapies." Journal of Nurse-Midwifery (1996) May;41(3):195-210.

Lieberman SA, Hoffman AR: "The somatopause: should growth hormone deficiency in older people Be treated?." Clinics in Geriatric Medicine (1997) Nov;13(4):671-684.

Marcus R, Hoffman AR: "Growth hormone as therapy for older men and women." Annual Review of Pharmacology and Toxicology (1998) 38:45-61.

Marcus R: "Skeletal effects of growth hormone and IGF-I in adults." Endocrine (1997) Aug;7(1):53-55.

Mariotti S, Franceschi C, Cossarizza A, Pinchera A: "The aging thyroid." Endocrine Reviews (1995) Dec;16(6):686-715.

McDonald RB: "Influence of dietary sucrose on biological aging." American Journal of Clinical Nutrition (1995) Jul;62(1 Suppl):284S-292S.

Merriam GR, Buchner DM, Prinz PN, Schwartz RS, Vitiello MV: "Potential applications of GH secretagogs in the evaluation and treatment of the age-related decline in growth hormone secretion." Endocrine (1997) Aug;7(1):49-52.

Mohan S, Baylink DJ: "Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases." Endocrine (1997) Aug;7(1):87-91.

Mooradian AD: "Normal age-related changes in thyroid hormone economy." Clinics in Geriatric Medicine (1995) May;11(2):159-169.

Muller DC, Elahi D, Tobin JD, Andres R: "The effect of age on insulin resistance and secretion: a review." Seminars in Nephrology (1996) Jul;16(4):289-298.

Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB: "Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone." International Journal of Obesity and Related Metabolic Disorders (1997) May;21(5):355-359.

Nyberg F: "Aging effects on growth hormone receptor binding in the brain." Experimental Gerontology (1997) Jul;32(4-5):521-528.

Ortmeyer HK, Bodkin NL, Hansen BC: "Adipose tissue glycogen synthetase activation by in vivoinsulin in spontaneously insulin-resistant and type 2 (non-insulin-dependent) diabetic rhesus monkeys." Diabetologia (1993);36:200-206.

Parker CR Jr, Mixon RL, Brissie RM, Grizzle WE: "Aging alters zonation in the adrenal cortex of men." Journal of Clinical Endocrinology and Metabolism (1997) Nov;82(11):3898-3901.

Parr T: "Insulin exposure controls the rate of mammalian aging." Mechanisms of Ageing and Development (1996) Jul 5;88(1-2):75-82.

Parr T: "Insulin exposure and aging theory." Gerontology (1997) 43(3):182-200.

Paul RG, Bailey AJ: "Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes." Int J Biochem Cell Biol (1996) Dec;28(12):1297-1310.

Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD: "Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males." Proceedings of the National Academy of Sciences of the United States of Ameri(1996) Nov 26;93(24):14100-14105.

Reiser KM: "Nonenzymatic glycation of collagen in aging and diabetes." Proceedings of the Society for Experimental Biology and Medicine (1998) May;218(1):23-37.

Reiter RJ, Carneiro RC, Oh CS: "Melatonin in relation to cellular antioxidative defense mechanisms." Horm Metab Res (1997) Aug;29(8) 363-372.

Reiter RJ, Guerrero JM, Escames G, Pappolla MA, Acuna-Castroviejo D: "Prophylactic actions of melatonin in oxidative neurotoxicity." Ann N Y Acad Sci (1997) Oct 15;825 70-78.

Reiter RJ, Pablos MI, Agapito TT, Guerrero JM: "Melatonin in the Context of the Free Radical Theory of Aging." Ann. N. Y. Acad. Sci. (1996) 786:362-378.

Reiter RJ : "Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals." European Journal of Endocrinology (1996) 143:421-420.

Reiter RJ : "Functional Diversity of the Pineal Hormone Melatonin Its Role as an Antioxidant." Experimental and Clinical Endocrinology & Diabetes (1996) 104:10-16.

Reiter RJ: "Functional pleiotropy of the neurohormone melatonin antioxidant protection and neuroendocrine regulation." Front Neuroendocrinol (1995) Oct;16(4) 383-415.

Reiter RJ: "Oxygen Detoxification Processes During Aging The Functional Importance of Melatonin." Aging Clin. Exp. Res. (1995) 7:340-351.

Reiter RJ: "Oxygen radical detoxification processes during aging the functional importance of melatonin." Aging (Milano) (1995) Oct;7(5) 340-351.

Reiter RJ: "The Pineal Gland and Melatonin in Relation to Aging: A Summary of the Theories and of the Data." Exp. Gerontol. (1995) 30:199-212.

Rice MM, Graves AB, McCurry SM, Larson EB: "Estrogen replacement therapy and cognitive function in postmenopausal women without dementia." Am J Med. (1997) Sep 22;103(3A) 26S-35S.

Robinson G: "Cross-cultural perspectives on menopause." Journal of Nervous and Mental Disease (1996) Aug;184(8):453-458.

Rosen CJ, Conover C: "Growth hormone/insulin-like growth factor-I axis in aging: a summary of a National Institutes of Aging-Sponsored Symposium." Journal of Clinical Endocrinology and Metabolism (1997) Dec;82(12):3919-3922.

Rosen CJ : "Growth hormone, IGF-I, and the elderly. Clues to potential therapeutic interventions." Endocrine. (1997) Aug;7(1) 39-40.

Scharbo-Dehaan M : "Hormone replacement therapy." Nurse Pract. (1996) Dec;21(12 Pt 2) 1-13.

Seeman TE, McEwen BS, Singer BH, Albert MS, Rowe JW: "Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging." Journal of Clinical Endocrinology and Metabolism (1997) Aug;82(8):2458-2465.

Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC, Rajakumar G : "Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease." Am J Med. (1997) Sep 22;103(3A) 19S-25S.

Singh I, Marshall MC Jr: "Diabetes mellitus in the elderly." Endocrinology and Metabolism Clinics of North America (1995) Jun;24(2):255-272.

Soffa VM: "Alternatives to hormone replacement for menopause. Part 1: Implications for the elderly." Alternative Therapies in Health and Medicine (1996) Mar;2(2):34-39.

Sulcova J, Hill M, Hampl R, Starka L: "Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects." Journal of Endocrinology (1997) Jul;154(1):57-62.

Tenover JS: "Androgen administration to aging men." Endocrinology and Metabolism Clinics of North America (1994);Dec;23(4):877-892.

Thorpe SR, Baynes JW: "Role of the Maillard reaction in diabetes mellitus and diseases of aging." Drugs and Aging (1996) Aug;9(2):69-77.

Touitou Y: "Effects of ageing on endocrine and neuroendocrine rhythms in humans." Hormone Research (1995) 43(1-3):12-19.

Veldhuis JD, Iranmanesh A, Weltman A: "Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans." Endocrine (1997) Aug;7(1):41-48.

Vermeulen A, Kaufman JM: "Ageing of the hypothalamo-pituitary-testicular axis in men." Hormone Research (1995) 43(1-3):25-28.

Wilkinson CW, Peskind ER, Raskind MA: "Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging." Neuroendocrinology (1997) Jan;65(1):79-90.

Wolf OT, Neumann O, Hellhammer DH, Geiben AC, Strasburger CJ, Dressendorfer RA, Pirke KM, Kirschbaum C: "Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men." Journal of Clinical Endocrinology and Metabolism (1997) Jul;82(7):2363-2367.

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